Hemodynamic Surrogates for Excitatory Membrane Potential Change During Interictal Epileptiform Events in Rat Neocortex
نویسندگان
چکیده
منابع مشابه
Hemodynamic surrogates for excitatory membrane potential change during interictal epileptiform events in rat neocortex.
Hemodynamic changes in the brain are often used as surrogates for epileptic neuronal activity in both the laboratory and the clinic (e.g., intrinsic signal, functional magnetic resonance imaging and single-photon emission computed tomography) in spite of the fact that perfusion-based signals have been shown to overestimate the population of spiking neurons. In addition, mechanisms of neurovascu...
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We investigated the dynamic spatiotemporal relationships of cerebral blood volume (CBV), deoxygenated hemoglobin (Hbr), and light scatter (LS) associated with interictal epileptiform events with multiwavelength optical recording of intrinsic signals and simultaneous field potential recording. Interictal spikes (IISs) were induced with iontophoresis of bicuculline methiodide in rat neocortex. In...
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PURPOSE Whether interictal epileptiform discharges (IEDs) increase, decrease, or are unchanged before epileptic seizures has implications for the pathophysiology of epilepsy. Prior studies relating IEDs and seizures have not demonstrated a change in IEDs before seizures. However, they have not controlled for changes in the depth of sleep. Our objective was to test the hypothesis that IEDs are r...
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We used voltage-sensitive dye imaging to visualize the distribution of initiation sites of the spontaneous interictal-like spikes (sISs) in rat neocortex, in vivo, induced by bicuculline or picrotoxin over the exposed cortex. The initiation site was small (approximately 200 microm diam). On average each initiation site initiated 2.0 +/- 0.8 sISs (9 animals, 499 sISs, 251 sites). This is signifi...
متن کاملInterictal Epileptiform Discharges
EEG remains the primary technique in the diagnosis, characterization, and localization of partial seizures. This review examines the significance and character of interictal epileptiform abnormailites, periodic lateralized epileptiform discharges, and ictal patterns in patients with partial epilepsy. Interictal epileptiform discharges are common and assist in the diagnosis and localization of p...
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ژورنال
عنوان ژورنال: Journal of Neurophysiology
سال: 2009
ISSN: 0022-3077,1522-1598
DOI: 10.1152/jn.90694.2008